1,3,2-Dioxathiane,4-methyl-, 2-oxide
Names
[ CAS No. ]:
4426-51-1
[ Name ]:
1,3,2-Dioxathiane,4-methyl-, 2-oxide
[Synonym ]:
4-methyltrimethylene sulphite
1,3-Butylene sulphite
cis-4-methyl-r-2-oxo-1,3,2-dioxathiane
4-Methyltrimethylene sulfite
EINECS 224-608-2
1,3-butylene glycol sulfite
4-methyl-2-oxo-1,3,2-dioxathiane
trans-4-methyl-r-2-oxo-1,3,2-dioxathiane
FDA 0477
Chemical & Physical Properties
[ Density]:
1.36 g/cm3
[ Boiling Point ]:
185ºC at 760 mmHg
[ Melting Point ]:
5℃
[ Molecular Formula ]:
C4H8O3S
[ Molecular Weight ]:
136.17000
[ Flash Point ]:
69.3ºC
[ Exact Mass ]:
136.01900
[ PSA ]:
54.74000
[ LogP ]:
1.25620
[ Appearance of Characters ]:
liquid
[ Index of Refraction ]:
1.529
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EK1225000
- CHEMICAL NAME :
- 1,3-Butanediol, cyclic sulfite
- CAS REGISTRY NUMBER :
- 4426-51-1
- BEILSTEIN REFERENCE NO. :
- 1237514
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C4-H8-O3-S
- MOLECULAR WEIGHT :
- 136.18
- WISWESSER LINE NOTATION :
- T6OSOTJ BO D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 780 mg/kg/13D-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Blood - changes in bone marrow (not otherwise specified)
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 560 mg/kg/14D-I
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
- REFERENCE :
- NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%