CSV0C018875

Names

[ CAS No. ]:
442150-41-6

[ Name ]:
CSV0C018875

Biological Activity

[Description]:

CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

G9a

[In Vitro]

CSV0C018875 (2.5-20 μM; 48 hours) inhibits the levels of H3K9me2 modifications in the histones[1]. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 2.5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited the enzymatic activity of G9a in a dose-dependent manner in HEK293 cells.

[References]

[1]. M Ramya Chandar Charles, et al. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening. Biochimie. 2020 Jan;168:220-230.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇ClN₂O

[ Molecular Weight ]:
312.79

Related Compounds

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