cis-4-Hydroxy-L-proline hydrochloride

Names

[ Name ]:
cis-4-Hydroxy-L-proline hydrochloride

[Synonym ]:
(4S)-4-Hydroxy-L-proline hydrochloride (1:1)
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride
(4R)-4-Hydroxy-D-proline hydrochloride (1:1)
cis-4-Hydroxy-L-proline Hydrochloride
L-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1)
(4S)-4-hydroxy-L-proline hydrochloride
D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1)

Biological Activity

[Description]:

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅H₁₀ClNO₃

[ Molecular Weight ]:
167.591

[ Exact Mass ]:
167.034927

[ PSA ]:
69.56000

MSDS

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Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%