LDN 91946

Names

[ Name ]:
LDN 91946

[Synonym ]:
3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
Thieno[2,3-b]pyridine-5-carboxylic acid, 3-amino-2-benzoyl-6,7-dihydro-6-oxo-
LDN-91946
MFCD03016619

Biological Activity

[Description]:

LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3).

[References]

References 1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. 2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129. View Related Products by Target Deubiquitinase (DUB)

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
714.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂N₆O

[ Molecular Weight ]:
314.316

[ Flash Point ]:
385.6±32.9 °C

[ Exact Mass ]:
314.036133

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.722

Related Compounds

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