Gentianine
Names
[ CAS No. ]:
439-89-4
[ Name ]:
Gentianine
[Synonym ]:
4-(2-hydroxyethyl)-5-vinylnicotinic acid δ-lactone
4-<2-Hydroxyaethyl>-5-vinyl-3-pyridin-carboxylic acid lacton
1H-Pyrano[3,4-c]pyridin-1-one, 5-ethenyl-3,4-dihydro-
5-VINYLPYRROLIDONE
4-(2-Hydroxyethyl)-5-vinylnicotinic lactone
5-Ethenyl-3,4-dihydro-1H-pyrano(3,4-c)pyridin-1-one
Gentianine
4-(2-Hydroxyethyl)-5-vinylnicotinic Acid d-Lactone
5-vinylpyrrolidinone
1H-Pyrano(3,4-c)pyridin-1-one, 3,4-dihydro-5-vinyl-
2-Pyrrolidinone,5-ethenyl
Erythricine
5-vinyl-pyrrolidin-2-one
UNII-C2PD310UXB
5-ethenyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one
5-Vinyl-3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
386.5±42.0 °C at 760 mmHg
[ Melting Point ]:
84-86ºC
[ Molecular Formula ]:
C10H9NO2
[ Molecular Weight ]:
175.184
[ Flash Point ]:
187.6±27.9 °C
[ Exact Mass ]:
175.063324
[ PSA ]:
39.19000
[ LogP ]:
1.73
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.604
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ1374500
- CHEMICAL NAME :
- 1H-Pyrano(3,4-c)pyridin-1-one, 3,4-dihydro-5-vinyl-
- CAS REGISTRY NUMBER :
- 439-89-4
- BEILSTEIN REFERENCE NO. :
- 0137011
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H9-N-O2
- MOLECULAR WEIGHT :
- 175.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 276 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,1341,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 7,1,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 25,258,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951
Safety Information
[ Hazard Codes ]:
Xi