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Coumetarol

Names

[ CAS No. ]:
4366-18-1

[ Name ]:
Coumetarol

[Synonym ]:
Cumetarolo
3,3'-(2-methoxyethane-1,1-diyl)bis(2-hydroxy-4h-chromen-4-one)
Cumetharol
Cumetarol
4,4'-dihydroxy-3,3'-(2-methoxy-ethane-1,1-diyl)-bis-chromen-2-one
1,1-Bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-aethan
Cumetarolo [DCIT]
1,1-bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-ethane
Coumetarolum
Coumetarol
UNII-UO1VQB3SPZ

Biological Activity

[Description]:

Coumetarol is a vitamin K antagonist.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

vitamin K[1]


[In Vitro]

Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent[1].

[References]

[1]. Vogel GM, et al. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thromb Res. 1989 Jun 1;54(5):399-410.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C21H16O7

[ Molecular Weight ]:
380.34800

[ Exact Mass ]:
380.09000

[ PSA ]:
110.11000

[ LogP ]:
3.08890

Safety Information

[ RIDADR ]:
UN 2811

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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