Diffractaic acid

Names

[ CAS No. ]:
436-32-8

[ Name ]:
Diffractaic acid

[Synonym ]:
2,4-dimethoxy-3,6-dimethylbenzoic acid 4'-carboxy-3'-hydroxy-2',5'-dimethylphenyl ester
diffractic acid
diffractaic acid
Diffractasaeure
Dirbizomic acid
DIFFRACTOIC ACID
Dirhizomic acid
DIFFRACTANIC ACID
diffratic acid

Biological Activity

[Description]:

Diffractaic acid, a major constituent of U. longissimi, acts as an effective proapoptotic agent in various disorders research[1]. Diffractaic acid is the analgesic and antipyretic component of Usnea diffracta[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[In Vivo]

Diffractaic acid shows an analgesic effect by Acetic acid-induced writhing and tail-pressure methods in mice[2].

[References]

[1]. Fehmi Odabasoglu, et al. Diffractaic acid, a novel proapoptotic agent, induces with olive oil both apoptosis and antioxidative systems in Ti-implanted rabbits. Eur J Pharmacol. 2012 Jan 15;674(2-3):171-8.

[2]. E Okuyama, et al. Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta. Planta Med. 1995 Apr;61(2):113-5.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
604.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₇

[ Molecular Weight ]:
374.38400

[ Flash Point ]:
214.2ºC

[ Exact Mass ]:
374.13700

[ PSA ]:
102.29000

[ LogP ]:
3.56040

[ Vapour Pressure ]:
1.74E-15mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH3708850

CHEMICAL NAME :: beta-Resorcylic acid, 3,6-dimethyl-, 4-(2,4-dimethoxy-3,6-dimethylbenzoate)

CAS REGISTRY NUMBER :: 436-32-8

BEILSTEIN REFERENCE NO. :: 2915070

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H22-O7

MOLECULAR WEIGHT :: 374.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 962 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,335,1981

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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