K41498

Names

[ Name ]:
K41498

Biological Activity

[Description]:

K41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively hypotension. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 can be used for hypotension study[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> CRFR

[References]

[1]. A Rühmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF(2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23(3):453-60.

[2]. A J Lawrence, et al. The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. Br J Pharmacol

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆₂H₂₇₆N₄₈O₄₆

[ Molecular Weight ]:
3632.22000

[ Exact Mass ]:
3630.07000

[ PSA ]:
1591.75000

[ LogP ]:
8.99130

Related Compounds

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