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Atecegatran metoxil

Names

[ CAS No. ]:
433937-93-0

[ Name ]:
Atecegatran metoxil

[Synonym ]:
Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab(OMe)
Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab(MeO)
AZD-0837

Biological Activity

[Description]:

Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

[References]

[1]. Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J. 2009;30(23):2897-2907.

[2]. Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost. 2010;103(3):604-612.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H23ClF2N4O5

[ Molecular Weight ]:
496.89200

[ Exact Mass ]:
496.13300

[ PSA ]:
126.48000

[ LogP ]:
3.18790

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds