TIE-2/VEGFR-2 kinase-IN-4

Names

[ CAS No. ]:
433224-29-4

[ Name ]:
TIE-2/VEGFR-2 kinase-IN-4

Biological Activity

[Description]:

TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

Tie2:5.2 mM (IC50)

VEGFR-2:5.1 nM (IC50)


[References]

[1]. Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H17F4N5O4

[ Molecular Weight ]:
539.44

Related Compounds

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