ML161

Names

[ Name ]:
ML161

[Synonym ]:
2-Bromo-N-[3-(butyrylamino)phenyl]benzamide
2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide
Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-
Benzamide (2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]
ML 161

Biological Activity

[Description]:

Parmodulin 2 (ML161),a probe, is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 inhibits platelet aggregation induced by a PAR1 peptide agonist or by thrombin and has shown cytoprotective effects[1, 2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

[Target]

PAR1[1]

[References]

[1]. Gandhi DM, et al. Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. Bioorg Med Chem. 2018 May 15;26(9):2514-2529.

[2]. Dockendorff C Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1Receptor. ACS Med Chem Lett. 2012 Mar 8;3(3):232-237.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
465.7±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇BrN₂O₂

[ Molecular Weight ]:
361.233

[ Flash Point ]:
235.4±24.6 °C

[ Exact Mass ]:
360.047333

[ PSA ]:
65.18000

[ LogP ]:
3.45

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.656

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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