Methyl 2-(bromomethyl)acrylate
Names
[ CAS No. ]:
4224-69-5
[ Name ]:
Methyl 2-(bromomethyl)acrylate
[Synonym ]:
Methyl 2-(bromomethyl)acrylate
2-Propenoic acid, 2-(bromomethyl)-, methyl ester (9CI)
2-(Bromomethyl)acrylic Acid Methyl Ester
methyl 2-(bromomethyl)prop-2-enoate
2-Propenoic acid, 2-(bromomethyl)-, methyl ester
MFCD00011697
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
187.1±0.0 °C at 760 mmHg
[ Molecular Formula ]:
C5H7BrO2
[ Molecular Weight ]:
179.012
[ Flash Point ]:
78.3±0.0 °C
[ Exact Mass ]:
177.962936
[ PSA ]:
26.30000
[ LogP ]:
1.88
[ Vapour Pressure ]:
0.6±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.471
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AS4900000
- CHEMICAL NAME :
- Acrylic acid, 2-(bromomethyl)-, methyl ester
- CAS REGISTRY NUMBER :
- 4224-69-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C5-H7-Br-O2
- MOLECULAR WEIGHT :
- 179.03
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1090-1048S
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H318-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
UN 2810 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AS4900000
[ HS Code ]:
2916190090
Synthetic Route
Customs
[ HS Code ]: 2916190090
[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
Articles
Bioorg. Med. Chem. Lett. 20 , 5757-62, (2010)
The enzyme MurA performs an essential step in peptidoglycan biosynthesis and is therefore a target for the discovery of novel antibacterial compounds. We report here the inhibition of MurA by natural ...
Diastereocontrolled synthesis of enantioenriched 3,4-disubstituted beta-prolines.J. Org. Chem. 72 , 398, (2007)
Enantioenriched 3,4-disubstituted beta-prolines have been prepared with a high diastereocontrol through a carbometalation reaction or through a domino Michael addition/carbometalation reaction.
Use of methyl 2-(bromomethyl) acrylate as a chain-transfer agent to yield functionalized macromonomers via conventional and living radical polymerizations. Bon, SAF, et al.Macromolecules 33(16) , 5819-5824, (2000)