p38 MAP Kinase Inhibitor Ⅵ

Names

[ Name ]:
p38 MAP Kinase Inhibitor Ⅵ

[Synonym ]:
Ethanone, 2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio]-1-(4-fluorophenyl)-
2-[(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl]-1-(4-fluorophenyl)ethanone

Biological Activity

[Description]:

p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor with an inhibition rate of 24%[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[References]

[1]. Cheeseright TJ, et al. Novel lead structures for p38 MAP kinase via FieldScreen virtual screening. J Med Chem. 2009 Jul 23;52(14):4200-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
517.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₃FN₂OS₂

[ Molecular Weight ]:
332.42

[ Flash Point ]:
266.6±30.1 °C

[ Exact Mass ]:
332.045319

[ LogP ]:
4.50

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.669