GNF-Pf-5660

Names

[ Name ]:
GNF-Pf-5660

[Synonym ]:
3-Quinolinecarboxylic acid, 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-, ethyl ester
Ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate

Biological Activity

[Description]:

An antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites; the digestive vacuole membrane-spanning transporter PfMDR1 is a determinant of parasite resistance to GNF-Pf-5660.

[References]

References 1. Vanaerschot M, et al. Nat Microbiol. 2017 Oct;2(10):1403-1414. View Related Products by Target Parasite

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
604.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₈ClNO₅

[ Molecular Weight ]:
481.968

[ Flash Point ]:
319.6±31.5 °C

[ Exact Mass ]:
481.165588

[ LogP ]:
4.17

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.611

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.