Carnidazole

Names

[ Name ]:
Carnidazole

[Synonym ]:
ME 108
Spartrix
Carnidazole
[2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioic Acid O-Methyl Ester
Carbamothioic acid, N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-, O-methyl ester
O-Methyl [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioate
EINECS 255-663-0
UNII-RH5KI819JG

Biological Activity

[Description]:

Carnidazole is an antiprotozoal agent of the nitroimidazole class. Carnidazole is used for the research of Trichomonas infection[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Antiprotozoal[1]

[References]

[1]. A Notowicz, et al. First Experiences With Single-Dose Treatment of Vaginal Trichomoniasis With Carnidazole (R 25831). Br J Vener Dis. 1977 Apr;53(2):129-31.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
422.8±51.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₂N₄O₃S

[ Molecular Weight ]:
244.271

[ Flash Point ]:
209.5±30.4 °C

[ Exact Mass ]:
244.063004

[ PSA ]:
116.99000

[ LogP ]:
0.72

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD3912000

CHEMICAL NAME :: Carbamothioic acid, (2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-, O-methyl ester

CAS REGISTRY NUMBER :: 42116-76-7

BEILSTEIN REFERENCE NO. :: 0620260

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4-O3-S

MOLECULAR WEIGHT :: 244.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 213 umol/L

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,51,1983

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
C

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
FD3912000

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 187-94, (2015)

A selective, sensitive and high performance liquid chromatography-tandem mass spectrometry (LC-(ESI)MS/MS) method has been developed and validated for the quantification of the potent antitubercular d...

In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica).

J. Vet. Pharmacol. Ther. 15(4) , 409-15, (1992)

Six out of eight different Trichomonas gallinae strains isolated from racing pigeons proved to be resistant to the nitroimidazole drugs ronidazole, carnidazole and metronidazole. The minimal cytocidal...

Structural characterization of drugs and oxygenated metabolites by laser microprobe mass spectrometry (LAMMA).

Biomed. Environ. Mass Spectrom. 16(1-12) , 121-9, (1988)

Laser microprobe mass analysis (LAMMA) was used for the structural characterization of polyfunctional drugs and their oxygenated metabolites, in particular the N-oxides. The spectra usually yield the ...