Glabranin

Names

[ CAS No. ]:
41983-91-9

[ Name ]:
Glabranin

[Synonym ]:
(2S)-5,7-Dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (2S)-
(2S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenyl-2,3-dihydro-4H-chromen-4-one
Glabranin
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-, (2S)-

Biological Activity

[Description]:

Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus[1].Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[References]

[1]. Sánchez I, et al. Antiviral effect of flavonoids on the dengue virus. Phytother Res. 2000 Mar;14(2):89-92.

[2]. Ismail NA, et al. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
545.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₄

[ Molecular Weight ]:
324.370

[ Flash Point ]:
197.1±23.6 °C

[ Exact Mass ]:
324.136169

[ PSA ]:
66.76000

[ LogP ]:
6.02

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.622

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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