2-Benzyl-4,5-dichloropyridazine-3(2H)-one

Names

[ CAS No. ]:
41933-33-9

[ Name ]:
2-Benzyl-4,5-dichloropyridazine-3(2H)-one

[Synonym ]:
2-benzyl-4,5-dichloropyridazin-3-one

Biological Activity

[Description]:

EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC50 of 1.7 μM and a Ki of 46 nM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[Target]

IC50: 1.7 μM (EcDsbB)[1] Ki: 46 nM (EcDsbB)[1]

[In Vitro]

EcDsbB-IN-9 (Compound 9) (0-100 μM) causes accumulation of reduced DsbA (EcDsbB substrate) and inhibits oxidation of DsbA with an IC50 of 8.5 ± 0.6 μM[1].

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
338ºC at 760 mmHg

[ Melting Point ]:
87ºC

[ Molecular Formula ]:
C₁₁H₈Cl₂N₂O

[ Molecular Weight ]:
255.10000

[ Flash Point ]:
158.2ºC

[ Exact Mass ]:
254.00100

[ PSA ]:
34.89000

[ LogP ]:
2.59840

[ Index of Refraction ]:
1.626

MSDS

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Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%