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N-(4-Nitrophenyl)-L-leucinamide

Names

[ CAS No. ]:
4178-93-2

[ Name ]:
N-(4-Nitrophenyl)-L-leucinamide

[Synonym ]:
MFCD00063681
EINECS 224-047-3
Pentanamide, 2-amino-4-methyl-N-(4-nitrophenyl)-, (2S)-
N-(4-Nitrophenyl)-L-leucinamide
h-leu-pna

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
454.5±30.0 °C at 760 mmHg

[ Melting Point ]:
88-90ºC

[ Molecular Formula ]:
C12H17N3O3

[ Molecular Weight ]:
251.282

[ Flash Point ]:
228.7±24.6 °C

[ Exact Mass ]:
251.126984

[ PSA ]:
100.94000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.589

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H319

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S36-S37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

PLoS ONE 10(2) , e0115859, (2015)

Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The M...

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor.

Pharmacol. Res. Commun. 16(6) , 533-8, (1984)

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor. The kinetic parameters of the inhibition of the leucine aminopeptidase by beta-phenyl cysteine are reported in this communication.

Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.

Mol. Divers. 17(1) , 123-37, (2013)

Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches w...


More Articles


Related Compounds

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