14-Deoxyandrographolide

Names

[ Name ]:
14-Deoxyandrographolide

[Synonym ]:
20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-one
14-Dehydro-browniin
14-Dehydrobrowniine
Aconitan-14-one,20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-,(1alpha,6beta,16beta)
14-deoxy andrographolide
Dehydrobrowniin
10-Dehydro-browniin
3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxyl-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
Deoxyandrographolide

Biological Activity

[Description]:

14-Deoxyandrographolide, a bioactive compound of Andrographis paniculata, has hepatoprotective efficacy. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Roy DN, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160(7):1823-43.

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
509.5ºC at 760 mmHg

[ Melting Point ]:
176-178ºC

[ Molecular Formula ]:
C₂₀H₃₀O₄

[ Molecular Weight ]:
334.45000

[ Flash Point ]:
177.3ºC

[ Exact Mass ]:
334.21400

[ PSA ]:
66.76000

[ LogP ]:
2.99180

[ Index of Refraction ]:
1.551

[ Storage condition ]:
2-8℃

14-Deoxyandrographolide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds