Hirsutal

Names

[ Name ]:
Hirsutal

[Synonym ]:
hirsutanonol
7,7-diphenyl-4,5,6,6a-tetrahydro-1H,3H-pyrrolo<1,2-c>oxazol-2-one
(5S)-1,7-Bis(3,4-dihydroxyphenyl)-5-hydroxy-3-heptanone
3-Heptanone, 1,7-bis(3,4-dihydroxyphenyl)-5-hydroxy-, (5S)-

Biological Activity

[Description]:

Hirsutanonol ((5S)-Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Lee MW, et al. Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica. Biol Pharm Bull. 2000 Apr;23(4):517-8.

[2]. Yadav D, et al. Antifilarial diarylheptanoids from Alnus nepalensis leaves growing in high altitude areas of Uttarakhand, India. Phytomedicine. 2013 Jan 15;20(2):124-32.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
679.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂O₆

[ Molecular Weight ]:
346.374

[ Flash Point ]:
378.8±28.0 °C

[ Exact Mass ]:
346.141632

[ PSA ]:
118.22000

[ LogP ]:
0.88

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%