Panicolin

Names

[ Name ]:
Panicolin

[Synonym ]:
SKULLCAPFLAVONE I
5-Hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-4H-chromen-4-one
4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-
Panicolin

Biological Activity

[Description]:

Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> MicroRNA

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

[References]

[1]. Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72(5):557-570.

[2]. Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46(5):821-830.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
573.6±50.0 °C at 760 mmHg

[ Melting Point ]:
254-256℃

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.29

[ Flash Point ]:
215.5±23.6 °C

[ Exact Mass ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2914509090

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Related Compounds

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