<Suppliers Price>

Bis-propargyl-PEG1

Names

[ CAS No. ]:
40842-04-4

[ Name ]:
Bis-propargyl-PEG1

[Synonym ]:
1-2 bis 2 propynyloxy ethane
1,2-bis(propargyloxy)ethane
1,2-di(2-propynyloxy)ethane
1,2-di-propargyloxyethane
1,2-dipropargyloxyethane
1,2-bis-prop-2-ynyloxy-ethane

Biological Activity

[Description]:

Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C8H10O2

[ Molecular Weight ]:
138.16400

[ Exact Mass ]:
138.06800

[ PSA ]:
18.46000

[ LogP ]:
0.28600

Related Compounds