unithiol
Names
[ CAS No. ]:
4076-02-2
[ Name ]:
unithiol
[Synonym ]:
2,3-Dimercaptopropylsulphonica
Dimaval
DIMERCAPTOPROPANESULPHONICACID
unitiol
Sodium 2,3-disulfanyl-1-propanesulfonate
2,3-DICHLORO-5-FORMYLPYRIDINE
2,3-dimercaptopropane-1-sulfonic acid sodium salt
EINECS 223-796-3
MFCD00007523
1-Propanesulfonic acid, 2,3-dimercapto-, monosodium salt
sodium 2,3-disulfanylpropane-1-sulfonate
SodiumDimercaptopropanesulfonate
unithiol
sodium 2,3-mercapto-1-propanesulfonate
antidote
Unithiolum
1-Propanesulfonic acid, 2,3-dimercapto-, sodium salt (1:1)
sodium 2,3-dimercaptopropane-1-sulfonate
UNII:690VN2L7TK
2,3-sulfonate
2,3-DIMERCAPTOPROPANESULPHONATE
Chemical & Physical Properties
[ Melting Point ]:
215 °C (dec.)
[ Molecular Formula ]:
C3H7NaO3S3
[ Molecular Weight ]:
210.271
[ Exact Mass ]:
209.945496
[ PSA ]:
143.18000
[ LogP ]:
0.84060
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 0.1 g/mL, clear
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TZ6420000
- CHEMICAL NAME :
- 1-Propanesulfonic acid, 2,3-dimercapto-, monosodium salt
- CAS REGISTRY NUMBER :
- 4076-02-2
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C3-H7-O3-S3.Na
- MOLECULAR WEIGHT :
- 210.27
- WISWESSER LINE NOTATION :
- WSO&1YSH1SH &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1055 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - withdrawal Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1098 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22709 mg/kg/36W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - changes in metals, not otherwise specified
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8190 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 105 gm/kg/10W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10500 mg/kg/10W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2730 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 28 gm/kg
- SEX/DURATION :
- female 26 week(s) pre-mating - 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 750 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 8(4),31,1974
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S24/25
[ WGK Germany ]:
3
[ RTECS ]:
TZ6420000
[ HS Code ]:
2930909090
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%