Yatein

Names

[ Name ]:
Yatein

[Synonym ]:
Yatein
(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydro-2(3H)-furanone
(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one
Deoxypodorhizone
Dihydroanhydropodorhizol
2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-, (3R,4R)-

Biological Activity

[Description]:

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

[References]

[1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85.

[2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
564.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₄O₇

[ Molecular Weight ]:
400.422

[ Flash Point ]:
246.2±28.8 °C

[ Exact Mass ]:
400.152191

[ PSA ]:
72.45000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.577

Precursor & DownStream

Precursor

DownStream

Related Compounds

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