IC 87361

Names

[ Name ]:
IC 87361

[Synonym ]:
4H-1-Benzopyran-4-one, 5-hydroxy-7-(4-morpholinyl)-2-phenyl-
5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one

Biological Activity

[Description]:

IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β; enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.

[References]

References 1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64. 2. Shinohara ET, et al. Cancer Res. 2005 Jun 15;65(12):4987-92. View Related Products by Target DNA-PK

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
590.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₇NO₄

[ Molecular Weight ]:
323.343

[ Flash Point ]:
310.9±30.1 °C

[ Exact Mass ]:
323.115753

[ LogP ]:
2.21

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds

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