Taribavirin hydrochloride

Names

[ Name ]:
Taribavirin hydrochloride

[Synonym ]:
Ribamidine hydrochloride
Viramidine hydrochloride
1-|A-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboximidamide Monohydrochloride
AVS 206

Biological Activity

[Description]:

Taribavirin hydrochloride is an inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus[1]. Taribavirin hydrochloride is a Ribavirin prodrug, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[Target]

Inosine monophosphate dehydrogenase[1]

[In Vitro]

Taribavirin hydrochloride (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 0 μM, 0.1 μM, 1 μM, 2 μM Incubation Time: 24 hours Result: Decreased MCF-7 cell growth.

[References]

[1]. Abd-Rabou AA, et al. Taribavirin and 5-Fluorouracil-Loaded Pegylated-Lipid Nanoparticle Synthesis, p38 Docking, and Antiproliferative Effects on MCF-7 Breast Cancer. Pharm Res. 2018 Feb 27;35(4):76.

[2]. Deming P, et al. Taribavirin in the treatment of hepatitis C. Expert Opin Investig Drugs. 2011 Oct;20(10):1435-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₄ClN₅O₄

[ Molecular Weight ]:
279.68100

[ Exact Mass ]:
279.07300

[ PSA ]:
150.50000

Precursor & DownStream

Precursor

DownStream

Related Compounds

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