p-Fluorobenzotrifluoride

Names

[ CAS No. ]:
402-44-8

[ Name ]:
p-Fluorobenzotrifluoride

[Synonym ]:
α,α,α,4-Tetrafluorotoluene
4-fluotobenzotrifluoride
4-Fluorobenzotrifluoride
p-Fluorotrif
p-Fluorobenzotrifluoride
4-(trifluoromethyl)-fluorobenzene
p-(Trifluoromethyl)fluorobenzene
FXFFR DF
4-tetrafluorotoluene
1-Fluoro-4-trifluoromethylbenzene
p-Fluoro(trifluoromethyl)benzene
1-Fluoro-4-(trifluoromethyl)benzene
4-fluoro-trifluoromethylbenzene
4-Fluorobezotrifluoride
4-FLUORO TRIFLUOROTOLUENE
4-FLUOROBENZOTRILFUORIDE
α,α,α,p-Tetrafluorotoluene
EINECS 206-944-1
MFCD00000399
Benzene, 1-fluoro-4-(trifluoromethyl)-
4-Fluorobenzotrifluo

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
104.4±35.0 °C at 760 mmHg

[ Melting Point ]:
−42-−41.7 °C(lit.)

[ Molecular Formula ]:
C₇H₄F₄

[ Molecular Weight ]:
164.100

[ Flash Point ]:
10.6±0.0 °C

[ Exact Mass ]:
164.024918

[ LogP ]:
2.95

[ Vapour Pressure ]:
35.8±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.406

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;Xi:Irritant;

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S16-S26-S33-S24/25

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of novel trifluoromethyl-bearing bifunctional acyl-acceptant arenes: 2,2'-bis(trifluoromethylated aryloxy)biphenyls.

J. Oleo Sci. 56(9) , 479-91, (2007)

Novel bifunctional acyl-acceptant biphenyls bearing trifluoromethylated aroyloxy groups were successfully synthesized in high yields via TfOH-mediated electrophilic aromatic aroylation of fluorobenzen...

Absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor.

J. Med. Chem. 31(7) , 1412-7, (1988)

Fluoxetine is a potent and selective inhibitor of the neuronal serotonin-uptake carrier and is a clinically effective antidepressant. Although fluoxetine is used therapeutically as the racemate, there...

Synthesis and appetite suppressant activity of 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes as conformationally rigid analogues of fluoxetine.

Bioorg. Med. Chem. 14(8) , 2535-44, (2006)

Several 1-aryloxy-2-substituted aminomethyltetrahydronaphthalenes (7-21) as conformationally rigid analogues of fluoxetine were synthesized and evaluated for their anorexigenic and antidepressant acti...