kievitone

Names

[ Name ]:
kievitone

[Synonym ]:
3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one
Kievitone

Biological Activity

[Description]:

Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Kievitone (0-40 μM; 4 天) 抑制雌激素受体 (ER) 阳性乳腺癌细胞株 MCF-7 和 T47D 以及 ER 阴性乳腺癌细胞株 SKBR3 的增殖 (IC50 值为 5-18 μM)[2]。 Kievitone (0-40 μM; 48 h) 抑制由胰岛素样生长因子 1、胰岛素样生长因子 2、碱性成纤维细胞生长因子或转化生长因子 α 刺激的 MCF-7 细胞的 DNA 合成[2]。 Cell Viability Assay[2] Cell Line: MCF-7, T47D and SKBR3 cells Concentration: 0-40 μM Incubation Time: 4 days Result: Inhibited breast cancer cell proliferation in a dose-dependent manner.

[References]

[1]. Smith DA, et, al. Kievitone: the principal antifungal component of “substance II” isolated from Rhizoctonia-infected bean tissues. 1973 Apr;3(14):179-84.

[2]. Hoffman R. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Biochem Biophys Res Commun. 1995 Jun 15;211(2):600-6.

Chemical & Physical Properties

[ Density]:
1.384g/cm3

[ Boiling Point ]:
639.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₆

[ Molecular Weight ]:
356.36900

[ Flash Point ]:
231.4ºC

[ Exact Mass ]:
356.12600

[ PSA ]:
107.22000

[ LogP ]:
3.37660

[ Index of Refraction ]:
1.663

Related Compounds

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