Lodenafil carbonate

Names

[ Name ]:
Lodenafil carbonate

[Synonym ]:
Lodenafil Carbonate

Biological Activity

[Description]:

Lodenafil carbonate, a dimer that acts as a prodrug delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED)[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

PDE5

[References]

[1]. Glina S, et al. Efficacy and tolerability of lodenafil carbonate for oral therapy in erectile dysfunction: a phase II clinical trial. J Sex Med. 2009 Feb;6(2):553-7.

[2]. Toque HA, et al. Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum. Eur J Pharmacol. 2008 Sep 4;591(1-3):189-95.

Chemical & Physical Properties

[ Boiling Point ]:
1109.0±75.0 °C(Predicted)

[ Melting Point ]:
229-231 °C

[ Molecular Formula ]:
C₄₇H₆₂N₁₂O₁₁S₂

[ Molecular Weight ]:
1035.20000

[ Exact Mass ]:
1034.41000

[ PSA ]:
279.13000

[ LogP ]:
5.04220

Related Compounds

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