2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

Names

[ Name ]:
2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

[Synonym ]:
Hydroperoxyisophosphamide
4-Hydroperoxyisophosphamid
4-Hydroperoxyifosfamid
asta6760
4-hydroperoxyisophosphamide

Biological Activity

[Description]:

4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB)[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53.

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
419.9ºC at 760mmHg

[ Molecular Formula ]:
C₇H₁₅Cl₂N₂O₄P

[ Molecular Weight ]:
293.08

[ Flash Point ]:
207.8ºC

[ Exact Mass ]:
292.01500

[ PSA ]:
80.84000

[ LogP ]:
2.02850

[ Index of Refraction ]:
1.525

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX2435000

CHEMICAL NAME :: Hydroperoxide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro- 2H-1,3,2-oxazaphospho rin- 4-yl-, P-oxide

CAS REGISTRY NUMBER :: 39800-28-7

LAST UPDATED :: 199310

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H15-Cl2-N2-O4-P

MOLECULAR WEIGHT :: 293.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

Related Compounds

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