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Asperosaponin VI

Names

[ CAS No. ]:
39524-08-8

[ Name ]:
Asperosaponin VI

[Synonym ]:
3-O-(triphenylmethyl)prop-1-yn-3-ol
Asperosaponin
D-Glucopyranose, 1-O-[(5ξ,8ξ,9ξ,10ξ,17ξ,18ξ)-3-(α-L-arabinopyranosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl]-6-O-D-glucopyranosyl-
1-O-[(5ξ,8ξ,9ξ,10ξ,17ξ,18ξ)-3-(α-L-Arabinopyranosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl]-6-O-D-glucopyranosyl-D-glucopyranose
Asperosaponin VI

Biological Activity

[Description]:

Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cardiovascular Disease

[References]

[1]. Niu Y, et al. Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway. Phytother Res. 2011 Nov;25(11):1700-6.

[2]. Li C, et al. Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways. Eur J Pharmacol. 2010 Dec 15;649(1-3):100-7.

Chemical & Physical Properties

[ Density]:
1.43

[ Boiling Point ]:
990.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C47H76O18

[ Molecular Weight ]:
929.096

[ Flash Point ]:
282.1±27.8 °C

[ Exact Mass ]:
928.503174

[ PSA ]:
294.98000

[ LogP ]:
4.18

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Precursor & DownStream

Precursor

DownStream

Related Compounds