4-Fluoro-2-(trifluoromethyl)aniline

Names

[ CAS No. ]:
393-39-5

[ Name ]:
4-Fluoro-2-(trifluoromethyl)aniline

[Synonym ]:
4-Fluoro-2-trifluoromethylaniline
MFCD00007831
2-Amino-5-fluorobenzotrifluoride
4-Fluoro-2-(trifluoromethyl)benzenamine
Benzenamine, 4-fluoro-2-(trifluoromethyl)-
4-Fluoro-2-(trifluoromethyl)aniline
α,α,α,4-Tetrafluoro-o-toluidine
2-Amino-5-fluorobenz
5-FLUORO-2-AMINOBENZOTRIFLUORIDE
EINECS 206-886-7
ZR DF BXFFF

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
174.7±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₅F₄N

[ Molecular Weight ]:
179.115

[ Flash Point ]:
72.2±0.0 °C

[ Exact Mass ]:
179.035812

[ PSA ]:
26.02000

[ LogP ]:
2.46

[ Vapour Pressure ]:
1.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Discovery of a novel acyl-CoA: cholesterol acyltransferase inhibitor: the synthesis, biological evaluation, and reduced adrenal toxicity of (4-phenylcoumarin)acetanilide derivatives with a carboxylic acid moiety.

Chem. Pharm. Bull. 59(11) , 1369-75, (2011)

As a part of our research for novel potent and orally available acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors that can be used as anti-atherosclerotic agents, we recently reported the discov...