(E)-Guggulsterone

Names

[ Name ]:
(E)-Guggulsterone

[Synonym ]:
Z-guggulsterone
UNII:9B259YE66O
E-guggulsterone
Pregna-4,17-diene-3,16-dione, (17E)-
trans-Guggulsterone
Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione
Pregna-4,17(20)-diene-3,16-dione, (17E)-
(17E)-Pregna-4,17(20)-diene-3,16-dione
GUGGULSTERONE E
GS,TRANS
GUGGULESTERONE E
GUGGULSTERONE, (E)-
Z-Guggulsteron

Biological Activity

[Description]:

(-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic drug derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. N. VERMA, et al. Pharmacokinetics of Guggulsterone after Intravenous and Oral Administration in Rats.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
463.3±45.0 °C at 760 mmHg

[ Melting Point ]:
170-171.5°

[ Molecular Formula ]:
C₂₁H₂₈O₂

[ Molecular Weight ]:
312.446

[ Flash Point ]:
172.3±25.7 °C

[ Exact Mass ]:
312.208923

[ PSA ]:
34.14000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.557

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H335

[ Precautionary Statements ]:
P261

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
37-52/53

[ Safety Phrases ]:
61-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.

Biochim. Biophys. Acta 1844(9) , 1684-93, (2014)

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative...

Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.

Int. Immunopharmacol. 26 , 194-202, (2015)

Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to...

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Mol. Pharmacol. 87(5) , 878-89, (2015)

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression ...

Related Compounds

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