2-Amino-3-[2-(4-nitrophenyl)-2-oxoethyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium bromide

Names

[ Name ]:
2-Amino-3-[2-(4-nitrophenyl)-2-oxoethyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium bromide

[Synonym ]:
Benzothiazolium, 2-amino-4,5,6,7-tetrahydro-3-[2-(4-nitrophenyl)-2-oxoethyl]-, bromide (1:1)
2-Amino-3-[2-(4-nitrophenyl)-2-oxoethyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium bromide

Biological Activity

[Description]:

p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].non-alcoholic fatty liver disease[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Apoptosis >> MDM-2/p53

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Metabolic Disease

[Target]

Caspase-3

[References]

[1]. Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol. 2013;37(2):97-103.

[2]. Zhang F, et al. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Res. 2016 Oct 14;44(18):8610-8620.

[3]. Derdak Z, et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol. 2013 Apr;58(4):785-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆BrN₃O₃S

[ Molecular Weight ]:
398.275

[ Exact Mass ]:
397.009552

Related Compounds

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