Isodeoxyelephantopin

Names

[ Name ]:
Isodeoxyelephantopin

[Synonym ]:
(3S,4R,8R,9Z,12S)-10-Methyl-5-methylene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0]pentadeca-1(15),9-dien-3-yl methacrylate
2-Propenoic acid, 2-methyl-, (3aR,4S,9S,11Z,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester
Isodeoxyelephantopin

Biological Activity

[Description]:

Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop.

[References]

[1]. Verma SS, et al. Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-κB Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer. Sci Rep. 2019 Nov 29;9(1):17980.

[2]. Yunna Kim, et al. Treatment of Hominis placenta pharmacopuncture for a patient with mild neurocognitive disorder: Case report. J Pharmacopuncture. 2019 Dec; 22(4): 279–283.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
584.3±50.0 °C at 760 mmHg

[ Melting Point ]:
150-153℃

[ Molecular Formula ]:
C₁₉H₂₀O₆

[ Molecular Weight ]:
344.358

[ Flash Point ]:
258.1±30.2 °C

[ Exact Mass ]:
344.125977

[ PSA ]:
78.90000

[ LogP ]:
1.51

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.556

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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