SNAP-7941

Names

[ Name ]:
SNAP-7941

[Synonym ]:
Methyl (4S)-3-({3-[4-(3-acetamidophenyl)-1-piperidinyl]propyl}carbamoyl)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
SNAP-7941
5-Pyrimidinecarboxylic acid, 1-[[[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]amino]carbonyl]-6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-, methyl ester, (6S)-
methyl (4S)-3-[(3-{4-[3-(acetylamino)phenyl]piperidin-1-yl}propyl)carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Biological Activity

[Description]:

SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM; inhibits food intake stimulated by central administration of MCH, reduces consumption of palatable food, decreases in body weight in rats with diet-induced obesity; also produces effects similar to clinically used antidepressants and anxiolytics in animal models of depression/anxiety. Obesity Discontinued

[References]

References 1. Borowsky B, et al. Nat Med. 2002 Aug;8(8):825-30. 2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. 3. Millan MJ, et al. Int J Neuropsychopharmacol. 2008 Dec;11(8):1105-22. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR) Obesity

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₃H₄₁F₂N₅O₆

[ Molecular Weight ]:
613.652

[ Exact Mass ]:
613.271179

[ LogP ]:
2.47

[ Index of Refraction ]:
1.572

Related Compounds

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