phacolysin

Names

[ Name ]:
phacolysin

[Synonym ]:
Disodium 5,12-dihydroquinoxalino[2,3-b]phenazine-2,9-disulfonate
phacolysin
MFCD08458873
Quinoxalino[2,3-b]phenazine-2,9-disulfonic acid, 5,12-dihydro-, sodium salt (1:2)
Azapentacene
Phacolin
Sodium 5,12-dihydroquinoxalino[2,3-b]phenazine-2,9-disulfonate

Biological Activity

[Description]:

Azapentacene sodium is an anti-cataract agent[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Shvachko AG, et al. [Chemiluminescence decrease of singlet oxygen in NaClO+H2O2 reaction in the presence of different anti-cataract drugs]. Biull Eksp Biol Med. 1991 Jul;112(7):42-4. Russian.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₀N₄Na₂O₆S₂

[ Molecular Weight ]:
488.405

[ Exact Mass ]:
487.983704

[ PSA ]:
188.52000

[ LogP ]:
4.27760

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD3655000

CAS REGISTRY NUMBER :: 3863-80-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H12-N4.2O3-S.2Na

MOLECULAR WEIGHT :: 458.38

WISWESSER LINE NOTATION :: T G6 E6 C666 BM FN MM QNJ &.NA..S-O3 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982

Related Compounds

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