NPD926

Names

[ Name ]:
NPD926

[Synonym ]:
2-Chloro-N-[4-(dimethylamino)benzyl]-N-[3-(4-isopropoxyphenyl)-3-phenylpropyl]acetamide
Acetamide, 2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-[4-(1-methylethoxy)phenyl]-3-phenylpropyl]-

Biological Activity

[Description]:

A small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion; preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells.

[References]

References 1. Kawamura T, et al. Biochem J. 2014 Oct 1;463(1):53-63. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
631.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₅ClN₂O₂

[ Molecular Weight ]:
479.053

[ Flash Point ]:
335.9±31.5 °C

[ Exact Mass ]:
478.238708

[ LogP ]:
6.35

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.585

Related Compounds

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