DA 3003-2

Names

[ Name ]:
DA 3003-2

[Synonym ]:
7-Chloro-6-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione
DA-3003-2
7-chloro-6-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione
5,8-Quinolinedione, 7-chloro-6-[[2-(4-morpholinyl)ethyl]amino]-

Biological Activity

[Description]:

DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

DA 3003-2 (0.3-30 µM; 48 h) 在 PC-3 细胞中显示出抗增殖活性，IC50 值为 5 µM[1]。 DA 3003-2 (5, 10 µM; 24, 1 h) 诱导细胞周期停滞在 G2/M 期并增加 PC-3 细胞中 P-tyr15 Cdc2 的表达[ 1]。 Cell Cytotoxicity Assay[1] Cell Line: PC-3 cells Concentration: 0.3-30 µM Incubation Time: 48 h Result: Showed antiproliferative efficacy in a dose-dependent manner with an IC50 value of 5 µM. Cell Cycle Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase. Western Blot Analysis[1] Cell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 1 h Result: Increased the expression of P-tyr15 Cdc2.

[References]

[1]. Nemoto K. G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). Exp Ther Med. 2010 Jul;1(4):647-650.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
478.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆ClN₃O₃

[ Molecular Weight ]:
321.759

[ Flash Point ]:
243.4±28.7 °C

[ Exact Mass ]:
321.088013

[ LogP ]:
0.33

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.626

Related Compounds

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