2,3,3',4,4',5-PCB

Names

[ Name ]:
2,3,3',4,4',5-PCB

[Synonym ]:
PCB No 156(Aroclor 1242)
1,1'-Biphenyl, 2,3,3',4,4',5-hexachloro-
PCB(Aroclor1221)
2,3,3',4,4',5-Hexachlorobiphenyl
2,3,3',4,4',5-PCB
PCB No 157(Aroclor 1254)
PCB(Aroclor1248)
1,2,3,4-tetrachloro-5-(3,4-dichlorophenyl)benzene

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
417.1±40.0 °C at 760 mmHg

[ Melting Point ]:
127°C

[ Molecular Formula ]:
C₁₂H₄Cl₆

[ Molecular Weight ]:
360.878

[ Flash Point ]:
208.7±24.7 °C

[ Exact Mass ]:
357.844421

[ LogP ]:
6.74

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV5359100

CHEMICAL NAME :: 1,1'-Biphenyl, 2,3,3',4,4',5-hexachloro-

CAS REGISTRY NUMBER :: 38380-08-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H4-Cl6

MOLECULAR WEIGHT :: 360.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33306 ug/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thymus weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 126,202,1994 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 480 mg/kg

SEX/DURATION :: female 10-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 91,246,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80 mg/kg

SEX/DURATION :: female 10-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 91,246,1987

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H315-H336-H361f-H373-H411

[ Precautionary Statements ]:
P201-P210-P273-P301 + P310-P304 + P340 + P312-P331

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F,Xn,N

[ Risk Phrases ]:
11-38-48/22-51/53-62-65

[ Safety Phrases ]:
9-16-29-33-36/37-61-62-60

[ RIDADR ]:
UN 1208 3/PG 2

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment.

Eur. J. Pharmacol. 293(1) , 77-85, (1995)

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB 126), or 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) on thyroid hormone metabolism were studied in 13-week fe...

Toxic potency of 2,3,3',4,4',5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat.

Toxicol. Appl. Pharmacol. 126(2) , 202-13, (1994)

Interactive effects on toxicity and biochemical parameters were studied between 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a 13-week feeding study of ...

Promotion of enzyme altered foci in female rat 2,3,3',4,4',5-hexachlorobiphenyl.

Toxicol. Appl. Pharmacol. 147(1) , 46-55, (1997)

The tumor promoting activity of 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) was studied in an initiation/promotion bioassay in female Sprague-Dawley rats initiated with N-nitrosodiethylamine after part...

Related Compounds

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