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Jolkinolide B

Names

[ CAS No. ]:
37905-08-1

[ Name ]:
Jolkinolide B

[Synonym ]:
(4aR,6aS,7aR,10aR,11aR,11bR,11cR)-4,4,8,11c-Tetramethyl-1,2,3,4,4a,5,6,11a,11b,11c-decahydrobisoxireno[3,4:1,10a]phenanthro[3,2-b]furan-9(7aH)-one
2-Piperazinecarboxamide,1,4-dibutyl-N-(2,6-dimethylphenyl)-,dinitrate
1,4-dibutyl-n-(2,6-dimethylphenyl)piperazine-2-carboxamide ntrite(1:2)
jokiolide B
jolkinolide B
Bisoxireno[3,4:1,10a]phenanthro[3,2-b]furan-9(7aH)-one, 1,2,3,4,4a,5,6,11a,11b,11c-decahydro-4,4,8,11c-tetramethyl-, (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-
2-Piperazinecarboxanilide,1,4-dibutyl-2',6'-dimethyl-,dinitrate
1,4-dibutyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide

Biological Activity

[Description]:

Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[Target]

IC50: apoptosis[1]


[References]

[1]. Wang, J., Zhou, Y., Bai, X. et al. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells 32, 451–457 (2011).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
497.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H26O4

[ Molecular Weight ]:
330.418

[ Flash Point ]:
219.8±28.8 °C

[ Exact Mass ]:
330.183105

[ PSA ]:
51.36000

[ LogP ]:
3.24

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
2-8℃

Related Compounds