Jolkinolide A

Names

[ Name ]:
Jolkinolide A

[Synonym ]:
2H-Oxireno[1,10a]phenanthro[3,2-b]furan-10(11bH)-one, 3,3a,4,5,6,7,7a,7b-octahydro-4,4,7a,11-tetramethyl-, (1aS,3aR,7aR,7bS,11bR)-
(5β,9β,10α,14β)-8,14:12,16-Diepoxyabieta-11,13(15)-dien-16-one
Jolkinolide A

Biological Activity

[Description]:

Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGF[1]

[In Vitro]

Jolkinolide A (20-100 μg/mL; 24 h) 提高 A549 细胞中 caspase-9 蛋白水平[1]。 Jolkinolide A (40-80 μg/mL; 24 h) 降低 A549 细胞中 Akt-STAT3-mTOR 蛋白的表达[1]。 Jolkinolide A (20-100 μg/mL; 24 h) 抑制人脐静脉内皮细胞 (HUVEC) 增殖和迁移，促进细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: A549 cells Concentration: 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL, and 100 μg/mL Incubation Time: 24 hours Result: Promoted caspase-9 protein expression in cells at 20-100 μg/mL.Inhibited expression levels of Akt, STAT3, and mTOR proteins in cells at 40-80 μg/mL.

[In Vivo]

Jolkinolide A (40 mg/kg; 腹腔注射; 每 3 天一次，持续 2 个月) 抑制小鼠A549细胞异种移植瘤模型中VEGF蛋白的表达[1]。 Animal Model: Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; once every 3 days for 2 months Result: Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration.

[References]

[1]. Shen L, et al. Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells. Med Sci Monit. 2017 Jan 14;23:223-237.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
479.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆O₃

[ Molecular Weight ]:
314.41864

[ Flash Point ]:
206.7±23.3 °C

[ Exact Mass ]:
314.188202

[ LogP ]:
4.70

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.