Fenoverine

Names

[ CAS No. ]:
37561-27-6

[ Name ]:
Fenoverine

[Synonym ]:
Fenoverine
Spasmopriv
EINECS 253-552-1

Biological Activity

[Description]:

Fenoverine is an antispasmodic drug and inhibits calcium channel currents[1]. Fenoverine induces rhabdomyolysis[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[References]

[1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70.

[2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep;14(3):143-6.

Chemical & Physical Properties

[ Density]:
1.343g/cm3

[ Boiling Point ]:
671.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₂₅N₃O₃S

[ Molecular Weight ]:
459.56

[ Flash Point ]:
360.1ºC

[ Exact Mass ]:
459.16200

[ PSA ]:
70.55000

[ LogP ]:
4.30320

[ Index of Refraction ]:
1.678

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN5445000

CHEMICAL NAME :: 10H-Phenothiazine, 10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)ace tyl)-

CAS REGISTRY NUMBER :: 37561-27-6

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H25-N3-O3-S

MOLECULAR WEIGHT :: 459.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2874 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 15,37,1989

Related Compounds

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