Wilfortrine

Names

[ Name ]:
Wilfortrine

[Synonym ]:
(1S,3R,18S,19R,20R,21R,22S,23R,24R,25R,26R)-20,22,23,25-Tetraacetoxy-21-(acetoxymethyl)-15,26-dihydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.0.0.0]hexac osa-7,9,11-trien-19-yl 3-furoate

Biological Activity

[Description]:

Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[References]

[1]. Ouyang XK, et, al. Simultaneous determination of four sesquiterpene alkaloids in Tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatography. Phytochem Anal. Jul-Aug 2007;18(4):320-5.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
884.4±65.0 °C at 760 mmHg

[ Melting Point ]:
237.5-238.0°C(lit.)

[ Molecular Formula ]:
C₄₁H₄₇NO₂₀

[ Molecular Weight ]:
873.807

[ Flash Point ]:
488.6±34.3 °C

[ Exact Mass ]:
873.269165

[ PSA ]:
286.12000

[ LogP ]:
4.12

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.592