STAT6-IN-3

Names

[ CAS No. ]:
371919-80-1

[ Name ]:
STAT6-IN-3

Biological Activity

[Description]:

STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> JAK/STAT Signaling >> STAT
Research Areas >> Inflammation/Immunology

[References]

[1]. Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58(22):8970-84.  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H35IN3O7P

[ Molecular Weight ]:
731.51

Related Compounds