Mibolerone
Names
[ CAS No. ]:
3704-09-4
[ Name ]:
Mibolerone
[Synonym ]:
MIBOLERONE
U-10,997
Miboleron
CDB 904
Miboleronum
[3H]-Mibolerone
MFCD00221774
(7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Cheque
Mibolerona
EINECS 223-046-5
Chemical & Physical Properties
[ Density]:
1.1g/cm3
[ Boiling Point ]:
440.5ºC at 760mmHg
[ Melting Point ]:
168-171ºC
[ Molecular Formula ]:
C20H30O2
[ Molecular Weight ]:
302.45100
[ Flash Point ]:
187.8ºC
[ Exact Mass ]:
302.22500
[ PSA ]:
37.30000
[ LogP ]:
4.12520
[ Index of Refraction ]:
1.553
[ Storage condition ]:
Controlled Substance, -20?C Freezer
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7980000
- CHEMICAL NAME :
- Estr-4-en-3-one, 17-beta-hydroxy-7-alpha,17-dimethyl-
- CAS REGISTRY NUMBER :
- 3704-09-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C20-H30-O2
- MOLECULAR WEIGHT :
- 302.50
- WISWESSER LINE NOTATION :
- L E5 B666 OVTJ E1 FQ F1 K1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 8985 ug/kg/9.6Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 13,177,1985 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 800 ug/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 9,235,1967
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 196 ug/kg
- SEX/DURATION :
- female 6-61 day(s) after conception lactating female 42 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940- Volume(issue)/page/year: 39,837,1978
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H360
[ Precautionary Statements ]:
P201-P308 + P313
[ Hazard Codes ]:
T
[ Risk Phrases ]:
60-63
[ Safety Phrases ]:
36-45
[ RIDADR ]:
NONH for all modes of transport
Articles
J. Steroid Biochem. Mol. Biol. 111(3-5) , 275-81, (2008)
In this study, we report the synthesis and biological evaluation of several new 3-substituted pregna-4,16-diene-6,20-dione derivatives (11a-11d). These compounds were prepared from the commercially av...
Steroid and beta-adrenergic receptor modifications in target organs of broiler chickens fed with a diet containing beta2-adrenergic agents.Food Chem. Toxicol. 46(6) , 2239-43, (2008)
The illegal use of beta2-agonists as repartitioning agents to improve production performance and carcass composition can induce changes in various organs of exposed animals. The aim of the present stu...
Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase.J. Steroid Biochem. Mol. Biol. 107(1-2) , 48-56, (2007)
In order to study the biological activity of the two novel steroidal carbamates derivatives: 8a and 8b, we determined the concentration of both compounds that inhibit the 50% of the activity of human ...