oxyphyllenone a

Names

[ Name ]:
oxyphyllenone a

[Synonym ]:
2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-7,8-dihydroxy-4a,8-dimethyl-, (4aR,7R,8R)-
(4aR,7R,8R)-7,8-dihydroxy-4a,8-dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one
(4aR,7R,8R)-7,8-Dihydroxy-4a,8-dimethyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone

Biological Activity

[Description]:

Oxyphyllenone A is an inhibitor of NO Synthase. Oxyphyllenone A inhibits the NO production in lipopolysaccharide-activated macrophages with an IC50 of 28 μM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. Muraoka O, et al. Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2217-20.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
357.8±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₈O₃

[ Molecular Weight ]:
210.27

[ Flash Point ]:
184.4±24.4 °C

[ Exact Mass ]:
210.125595

[ PSA ]:
57.53000

[ LogP ]:
0.51

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.553

Related Compounds

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