2-amino-2-(2,3,4,5,6-pentadeuteriophenyl)acetic acid

Names

[ Name ]:
2-amino-2-(2,3,4,5,6-pentadeuteriophenyl)acetic acid

[Synonym ]:
D,L-2-Phenylglycine-d5

Biological Activity

[Description]:

2-Phenylglycine-d5 (DL-α-Phenylglycine-d5) is the deuterium labeled 2-Phenylglycine. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Alexandre-Gouabau MC, et al. Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early GrowthPattern. Nutrients. 2019 Feb 28;11(3).

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₄D₅NO₂

[ Molecular Weight ]:
156.19300

[ Exact Mass ]:
156.09500

[ PSA ]:
63.32000

[ LogP ]:
1.47130

Related Compounds

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