Ibuprofen impurity 1

Names

[ Name ]:
Ibuprofen impurity 1

[Synonym ]:
Benzeneacetic acid, α-methyl-4-propyl-
2-(4-Propylphenyl)propanoic acid
|A-Methyl-4-propylphenylacetic Acid
|A-Methyl-4-propylbenzeneacetic Acid
2-(4-n-propylphenyl)propionic acid
p-Propylhydratropic Acid

Biological Activity

[Description]:

Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
310.5±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆O₂

[ Molecular Weight ]:
192.254

[ Flash Point ]:
207.5±14.4 °C

[ Exact Mass ]:
192.115036

[ PSA ]:
37.30000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.525

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%