rosamicin
Names
[ CAS No. ]:
35834-26-5
[ Name ]:
rosamicin
[Synonym ]:
Rosaramicina [INN-Spanish]
Cirramycin A1,4'-deoxy
2-[(14E)-9-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]acetaldehyde
Antibiotic 67-694
Juvenimicin A3 Rosaramicin
ROSAMICIN
Juvenimicin A3
Rosaramicine [INN-French]
Antibiotic M 4365A2
Rosaramicin
Rosaramicinum [INN-Latin]
Chemical & Physical Properties
[ Density]:
1.17g/cm3
[ Boiling Point ]:
734.7ºC at 760mmHg
[ Melting Point ]:
119-122°
[ Molecular Formula ]:
C31H51NO9
[ Molecular Weight ]:
581.73800
[ Flash Point ]:
398.1ºC
[ Exact Mass ]:
581.35600
[ PSA ]:
135.13000
[ LogP ]:
2.67040
[ Index of Refraction ]:
1.532
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JG6800000
- CHEMICAL NAME :
- 4,17-Dioxabicyclo(14.1.0)heptadec-14-ene-10-acetaldeh yde, 3-ethyl-7-hydroxy-2,8,12,16- tetramethyl-5,13-dioxo-9-((3,4,6-trideoxy-3-(dimethyl amino)-beta-D-xylo-he xopyranosyl)oxy)-
- CAS REGISTRY NUMBER :
- 35834-26-5
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C31-H51-N-O9
- MOLECULAR WEIGHT :
- 581.83
- WISWESSER LINE NOTATION :
- T3-16- BO FOV OV PUTJ A1 D1 E2 IQ J1 L1VH N1 KO- BT6OTJ CQ DN1&1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,647,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 43,938,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,641,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4800 mg/kg/30D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,129,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
20/21/22
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
JG6800000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Antibiot. 25 , 641, (1972)
Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.
Antimicrob. Agents Chemother. 57(3) , 1529-31, (2013)
The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by...
Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.J. Bacteriol. 174(1) , 161-5, (1992)
Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activi...